清末民(mín )初,佛山(shān )武学宗师黄飞鸿(hóng )因噩梦预感(gǎn )女记者(zhě )莫十三遇险,携弟子前往古云村寻人(rén )。村中蜈蚣教借蛊术胁迫村民献祭孩(hái )童,莫十三探查真相时被擒,身中噬魂(hún )蛊。黄飞(fēi )鸿闯祭坛救人,因(yīn )不忍伤及被(bèi )蛊惑的(de )村民反中蛊毒,幸(xìng )得卧底蜈蚣(gōng )教的鬼(guǐ )脚七暗中相助。众(zhòng )人合力破除(chú )水源蛊(gǔ )毒,救治村民,鬼脚(jiǎo )七伤愈拜师(shī )。巫师自(zì )焚后,线索指向广州东瀛会馆(guǎn )。黄飞鸿(hóng )潜入会馆救出被掳孩童,对决主事服(fú )部一郎,得知幕后黑手为西洋吸血鬼(guǐ )麦克罗。麦克罗散播疫毒(dú )祸乱羊城,以(yǐ )莫十三(sān )性命相要挟。黄飞(fēi )鸿于绝境中(zhōng )融合腿(tuǐ )法,悟出佛山无影(yǐng )脚,击杀麦克(kè )罗。蛊毒(dú )尽解,百姓恢复神(shén )智,广